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Semaglutide is sold under three names with three different schedules. Here is every dose — Wegovy and Ozempic weekly injections and the Rybelsus daily pill — the week-by-week titration, and why it always starts at a dose that barely works.
| Brand | Form | Titration | Maintenance |
|---|---|---|---|
| Wegovy (weight loss) | Weekly injection | 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg | 2.4 mg/week |
| Ozempic (type 2 diabetes) | Weekly injection | 0.25 → 0.5 → 1.0 → 2.0 mg | 0.5–2.0 mg/week |
| Rybelsus (type 2 diabetes) | Daily oral pill | 3 → 7 → 14 mg | 7–14 mg/day |
Each step is held roughly 4 weeks before moving up. Your prescriber may hold a step longer if you have significant nausea — that is normal, not a setback.
The 0.25 mg starting injection (and the 3 mg starting pill) is sub-therapeutic by design — too low to drive much weight loss, chosen only to let your gut adapt and blunt the nausea that a higher starting dose would cause. That is why month one feels underwhelming: you are on a tolerance dose, not the treatment dose. Skipping the ramp is not an option — going straight to 2.4 mg would make most people miserably sick. See the week-by-week experience in the Wegovy timeline.
Same molecule, different targets and tops. Wegovy is dosed for weight loss and climbs highest (2.4 mg). Ozempicis dosed for blood sugar and tops out at 2.0 mg. Rybelsus is the oral option, taken daily on an empty stomach with a sip of water and nothing else for 30 minutes, because absorption is finicky. For tirzepatide’s schedule instead, see the Zepbound dosage chart; to compare the molecules, read what is a GLP-1.
Weekly injectables: within 5 days, take it; past 5 days, skip and resume on your normal day. Rybelsus: skip the missed pill and take the next as scheduled. Miss more than ~2 weeks and your prescriber may re-titrate you from a lower dose. When in doubt, ask — do not double up.