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What to expect on Wegovy (semaglutide) from your first injection through maintenance: appetite changes, side-effect onset, and weight-loss milestones.
First weekly injection. Subtle reduction in appetite reported by some users within 24-48 hours. No clinically significant weight change.
Appetite suppression more consistent. Most users notice satiety changes — feeling full faster, less interest in food. Early weight loss ~1-3 lbs typical.
Titration progresses through 0.5 → 1 → 1.7 mg. Weight loss accelerates. STEP-1 cohort averaged 6% body weight loss at 12 weeks.
Maintenance dose (2.4 mg) reached around week 16-17. Weight loss continues steadily. STEP-1 averaged ~10% at 6 months.
Plateau or continued loss. STEP-1 averaged 14.9% at 68 weeks. Maintenance phase begins; weight regain risk if discontinued.
Editorial summary based on pivotal trial titration schedules and real-world reports. Individual timelines vary. Not medical advice.