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All GLP-1s are pregnancy category X. Calculate exact stop-date for safe conception, with IVF-specific protocols and metformin bridge guidance.
All GLP-1s are pregnancy category X
Animal studies show fetal harm. Confirm contraception until your calculated stop date. Wait at least 2 weeks after stopping before attempting conception. The 60-90 day washout allows complete drug clearance + hormonal/appetite recalibration.
Your situation
120 days until stop date. Plenty of runway. Use this time to optimize health markers (A1C, BMI, B12/folate).
Metformin bridge option:
If you need continued metabolic support (T2D, PCOS, insulin resistance), metformin (pregnancy category B) is the standard bridge during washout + early pregnancy. Discuss with endocrinologist or OB-GYN at least 30 days before stopping GLP-1.
Semaglutide half-life ~1 week. Two months provides 8+ half-lives = ~99.6% clearance.
All GLP-1s are pregnancy category X. Animal studies show fetal harm. Confirm contraception until stop date. Wait at least 2 weeks after stopping before attempting conception (allows hormonal/appetite signal recalibration).
At least 60 days (8-9 weeks) before attempting conception. Semaglutide half-life is ~1 week — 60 days provides 8+ half-lives = 99.6% clearance. Some clinicians extend to 90 days for extra safety.
Yes. Tirzepatide has a longer effective half-life. Standard recommendation is 75 days (10-11 weeks) before conception attempt, vs 60 days for semaglutide. Some specialists extend to 90+ days.
No. Stop GLP-1 at least 2-3 weeks before stim cycle starts (egg retrieval). For tirzepatide, stop ≥3 weeks before retrieval. GLP-1 effects on ovarian response and embryo viability are not established as safe.
Stop immediately and notify your OB-GYN. Document last dose date. Most prenatal exposures in early pregnancy have been observed without major fetal anomalies in real-world cohorts, but the FDA category X label is based on animal studies showing harm.
If you need continued metabolic support (T2D, PCOS, severe insulin resistance), metformin is pregnancy category B and the standard bridge during washout AND early pregnancy. Discuss with your endocrinologist or OB-GYN 30+ days before stopping GLP-1.