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Yes — 11% of patients on Wegovy 2.4 mg reported fatigue in the label's pooled trials, vs 5% on placebo. Causes: reduced caloric intake, GI side effects, sleep disruption from nausea.
Fatigue on Wegovy is common — 11% of patients on Wegovy 2.4 mg vs 5% on placebo in the label's pooled weight-loss trials. Mechanisms: (1) Reduced caloric intake (often -500 to -1000 kcal/day) during titration leaves body without usual energy supply. (2) GI side effects disrupt sleep. (3) Dehydration from reduced food/water intake. (4) Possibly direct GLP-1 effect on sleep architecture. Mitigation: adequate protein (1.4g/kg/day), iron + B12 + vitamin D check if persistent, electrolyte awareness (sodium loss), slower titration if severe. Persistent fatigue: rule out anemia, thyroid changes, sleep apnea.
Editorial answer verified against FDA labeling and peer-reviewed trials, with sources cited. Not medical advice. Coordinate treatment decisions with your prescriber.