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Most GI side effects (nausea, constipation, sulfur burps) resolve within 4-8 weeks as your body adjusts. Side effects flare again with each dose escalation.
Wegovy side effects follow a predictable pattern. Nausea, constipation, diarrhea, and sulfur-flavored burps are most intense in the first 4 weeks of starter dose (0.25mg) and during each 4-week dose escalation. Steady-state side effects diminish significantly once you reach maintenance dose (2.4mg) — typically by week 17. ~20% of patients discontinue within first 3 months due to intolerable GI effects. Strategies: take with small low-fat meals, hydrate aggressively, ask your clinician about anti-nausea support (ondansetron) during first month, slow titration if symptoms severe. Severe abdominal pain or persistent vomiting warrants immediate clinician contact — rule out gallstones or pancreatitis.
Editorial answer reviewed by a board-certified clinician. Not medical advice. Coordinate treatment decisions with your prescriber.