DisclosureWe earn commission on partner links; ranking is set by clinician-vetted methodology — not advertisers.
Complete dose-conversion chart, washout period, side effect management, and insurance considerations for moving from Tirzepatide to Semaglutide.
This is the standard equivalency between Tirzepatide and Semaglutide doses. Use it to discuss with your prescriber — never to self-titrate.
| Current (Tirzepatide) | Equivalent (Semaglutide) |
|---|---|
| 2.5 mg tirzepatide | → 0.25 mg semaglutide (titration start) |
| 5 mg tirzepatide | → 0.5 mg semaglutide |
| 7.5 mg tirzepatide | → 1.0 mg semaglutide |
| 10 mg tirzepatide | → 1.7 mg semaglutide |
| 15 mg tirzepatide | → 2.4 mg semaglutide |
Most prescribers wait 7 days between the last dose of Foundayo (oral tirzepatide) and the first dose of Wegovy. This allows the previous drug to clear the system and reduces the risk of GI side effects from overlapping action.
Restart at 0.25 mg semaglutide for at least 4 weeks regardless of prior tirzepatide dose.
Most prescribers recommend 7 days between the last Foundayo (oral tirzepatide) dose and the first Wegovy dose. Always confirm with your prescriber.
Wegovy is a different molecule. Even if you tolerated a high dose of Foundayo (oral tirzepatide), your body needs to re-adapt. Restart at 0.25 mg semaglutide for at least 4 weeks regardless of prior tirzepatide dose.
Most plans require prior authorization for the new drug, with documentation of why the switch is medically necessary (efficacy plateau, side effect intolerance, cost). Have your prescriber's office prepare a PA before the switch.
Considering Wegovy? See offers from telehealth providers and pharmacies.
See offer →