DisclosureWe earn commission on partner links; ranking is set by our published methodology — not advertisers.
Three approved sites: abdomen (2 inches from navel), front of thigh, upper outer arm (with help). Rotate weekly to prevent lipohypertrophy (fat thickening).
FDA-approved injection sites: (1) Abdomen — 2 inches from navel, anywhere within a hand's-width radius. Most common choice. (2) Front of thigh — middle third, away from knee and groin. (3) Upper outer arm — requires assistance to reach. Rotate sites WEEKLY to prevent lipohypertrophy (fatty tissue thickening that reduces absorption). Visual rotation map: week 1 right abdomen, week 2 left abdomen, week 3 right thigh, week 4 left thigh, repeat. Mark with sticker on calendar or phone app. Skin should be clean (alcohol wipe, air dry), free of scars, stretch marks, bruises.
Editorial answer verified against FDA labeling and peer-reviewed trials, with sources cited. Not medical advice. Coordinate treatment decisions with your prescriber.