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Yes. Wegovy slows gastric emptying, reducing levothyroxine absorption. Space them 4+ hours apart and monitor TSH 6-8 weeks after starting Wegovy.
Levothyroxine (Synthroid) absorption is highly dependent on rapid gastric emptying and an empty stomach. Wegovy slows gastric emptying 2-4x, reducing levothyroxine bioavailability and potentially destabilizing thyroid hormone levels. Mitigation: (1) Take levothyroxine FIRST thing AM with water only, then wait 30-60 minutes before food or Wegovy injection. (2) Check TSH 6-8 weeks after starting Wegovy AND after each dose escalation. (3) Hypothyroid patients may need 10-30% dose increase. Hashimoto's autoimmune thyroiditis: same management, with autoimmune monitoring.
Editorial answer verified against FDA labeling and peer-reviewed trials, with sources cited. Not medical advice. Coordinate treatment decisions with your prescriber.