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Yes, potentially. Wegovy slows gastric emptying, which can reduce oral contraceptive absorption. Use backup contraception during titration and add 4 weeks after each dose increase.
Wegovy may reduce absorption of oral contraceptive pills due to delayed gastric emptying. The FDA label recommends adding a backup non-oral method (condom, IUD, implant) during the first 4 weeks of treatment AND for 4 weeks after each dose increase. Long-acting reversible contraception (LARC) — IUD or implant — is not affected by GLP-1s. If you rely on oral contraception, discuss with your prescriber. Anecdotal reports of unintended pregnancy ("Ozempic babies") may reflect this interaction plus PCOS-related fertility improvement.
Editorial answer verified against FDA labeling and peer-reviewed trials, with sources cited. Not medical advice. Coordinate treatment decisions with your prescriber.