DisclosureWe earn commission on partner links; ranking is set by clinician-vetted methodology — not advertisers.
Average ~15% of body weight at 68 weeks based on the STEP-1 trial. Real-world adherent users lose 12-18% in the first year.
Clinical trial data: the STEP-1 trial showed adults on Wegovy lost an average of ~15% of starting body weight at 68 weeks vs ~2% in placebo group. For a 200-pound person, that is roughly 30 pounds. Real-world results vary: adherent users with lifestyle support lose 12-18% in year one. Discontinuation within 3 months drops average loss to 5-8%. After 12-18 months, weight loss plateaus as the body adapts. Continued use is required to maintain loss — within 12 months of discontinuation, ~60% of lost weight typically returns. Factors increasing weight loss: higher starting BMI, strict adherence, resistance training, adequate protein intake, dose escalation to full 2.4mg maintenance. Factors decreasing: dose reductions, GI side-effect-driven food restriction (counterintuitively), inadequate protein intake leading to lean mass loss.
Editorial answer reviewed by a board-certified clinician. Not medical advice. Coordinate treatment decisions with your prescriber.