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Weight loss of 10% or more over 6-12 months has been linked to 1.0-2.7% losses in hip bone mineral density. GLP‑1 medications may have direct bone-protective effects, but human data is limited. STEP 1 did not measure bone density, so it cannot answer whether Wegovy specifically changes it.
Weight loss of 10% or more over 6–12 months has been associated with 1.0%–2.7% losses in hip bone mineral density. GLP-1 medications may have direct bone-protective effects (animal studies show GLP-1 receptors on osteoblasts/osteoclasts), but human data is limited. STEP 1 measured fat and lean mass by DXA but did not report bone density, so it does not answer this question. Risk factors: postmenopausal women, older men, prior fracture history, low BMI to start. Mitigation: resistance training 2-3x/week (non-negotiable), adequate calcium (1200mg/day) + vitamin D (2000 IU/day), DEXA scan baseline + annual if high-risk.
Editorial answer verified against FDA labeling and peer-reviewed trials, with sources cited. Not medical advice. Coordinate treatment decisions with your prescriber.