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Yes — and you should. Exercise on Wegovy helps preserve lean muscle mass. In STEP 1's DXA substudy, about 5.8 kg of the 15.5 kg lost was lean mass (lean mass includes muscle, organs, bone and water, not muscle alone).
In STEP 1's DXA substudy, about 5.8 kg of the 15.5 kg lost on Wegovy was lean mass (lean mass includes muscle, organs, bone and water, not muscle alone). This becomes a long-term metabolic problem if you discontinue Wegovy. Recommendations: (1) Resistance training 2-3x/week is non-negotiable — protect muscle mass; (2) Cardiovascular exercise 150 minutes/week per CDC guidelines, but listen to your body — early-titration fatigue is normal; (3) Hydrate aggressively — GLP-1 dehydration risk is real, especially with high-intensity exercise; (4) Adequate protein intake (1.2-1.6g/kg body weight/day) supports muscle preservation. Many patients report exercise feels harder in first 4-8 weeks; this normalizes by maintenance dose.
Editorial answer verified against FDA labeling and peer-reviewed trials, with sources cited. Not medical advice. Coordinate treatment decisions with your prescriber.