Costco × Sesame: $349 Wegovy & Ozempic, explained

How the Costco × Sesame program works

Sesame is a cash-pay telehealth marketplace; in 2025 it partnered with Costco Pharmacy on a weight-loss program branded “Success by Sesame.” You complete a Sesame telehealth visit, and if a GLP-1 is appropriate, the prescription is filled through Costco Pharmacy at the negotiated cash rate — about $349/month for brand Wegovy or Ozempic. There is no insurance and no prior authorization; you pay cash, which is what makes it fast and predictable. In four steps:

1. Start a Sesame weight-loss visit (async — no appointment to schedule).
2. A licensed provider reviews your history and, if appropriate, prescribes Wegovy or Ozempic.
3. The script is filled at Costco Pharmacy at the ~$349/month cash rate (or $199 intro).
4. You refill monthly; a Sesame subscription/visit fee applies on top of the medication.

Check your Sesame price →

Who it fits — and who it doesn’t

Good fit: you want brand Wegovy or Ozempic, you’re paying cash (uninsured, or your plan denies weight-loss coverage), and you want the lowest verified price on the real FDA-approved drug. Not the fit: you want tirzepatide (Zepbound or Mounjaro) — the $349 rate is semaglutide-only, so use LillyDirect for Zepbound ($299–$449) instead; or you have insurance that already covers your GLP-1, in which case a covered copay or the Medicare $50 Bridge may beat cash.

How $349 compares to the other cash routes

Bottom line: Costco × Sesame and NovoCare Direct tie at ~$349/month for the real FDA-approved brand — the two cheapest verified routes. Compounded can be cheaper but is a different product with regulatory uncertainty. See the full ranking on the cheapest way to get a GLP-1, and the drug-by-drug math on what Wegovy costs.

The honest caveats

A Sesame visit/subscription fee applies on top of the $349 medication cost, so your all-in monthly is a bit higher than the drug price alone. The $349 rate is semaglutide-only — no tirzepatide. And like any cash route, nothing counts toward an insurance deductible or out-of-pocket max. If you can get a GLP-1 covered, compare that first; if not, this is among the cheapest doors to the real drug.